DNA display of glycoconjugates to emulate oligomeric interactions of glycans

• Alexandre Novoa and
• Nicolas Winssinger

Beilstein J. Org. Chem. 2015, 11, 707–719, doi:10.3762/bjoc.11.81

• programmability of the assemblies lends itself to a combinatorial display of multiple ligands. Recent efforts in the synthesis and applications of such conjugates are discussed. Keywords: glycan; glycoconjugate; DNA display; multivalency; nucleic acid conjugates; oligomeric interaction; Introduction Cell

• sugar-core glycoconjugate DNA. Combinatorial self-assembly of PNA glycoconjugates on a DNA microarray. General scheme of the 10,000 member PNA-encoded glycoconjugate library. Oligomeric interaction with arrayed mono- and divalent ligands (represented as the black spheres) as a function of surface